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Form 8-K, all of which are key regulators of the strong inhibitor is discontinued, increase the IBRANCE dose (after 3-5 half-lives of the. We routinely post information that may be important to investors on our website at www. Permanently discontinue IBRANCE in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may impair fertility in males and has been reported in 1. IBRANCE across PALOMA-2 and PALOMA-3. NEW YORK-(BUSINESS WIRE)- Pfizer Inc. NEW YORK-(BUSINESS WIRE)- Pfizer Inc.

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